Controversial topics in Neuroscience

Twitter thread here.

  • Do mice use vision much?
    • They have pretty crappy eyesight and their primary mode of exploration seems to be olfactory/whisker-based
  • How much is mouse cortex like primate cortex?
    • Mouse cortex is claimed to be more multimodal than primate cortex which is more specialized
  • “The brain does deep learning”
    • Deep learning units aren’t exactly like neurons, plus we resent the hype that they have been getting
  • Is there postnatal neurogenesis? Is it real or behaviorally relevant?
    • See recent paper saying it doesn’t exist in humans
  • Brain imaging
    • Does what we see correlate with neural activity? Are we able to correct for multiple comparisons correctly? Does anyone actually correct for multiple comparisons correctly?
  • Bayesian brain
    • Do people actually use their priors? Does the brain represent distributions? etc
  • Konrad Kording
    • Can neuroscientists understand a microprocessor? Is reverse correlation irrelevant?
  • Do mice have a PFC
    • It’s so small!
  • STDP: does it actually exist?
    • Not clear that neurons in the brain actually use STDP – often looks like they don’t. Same with LTP/LTD!
  • How useful are connectomes
    • About as useful as a tangled ball of yarn?
  • LTP is the storage mechanism for memories
    • Maybe it’s all stored in the extracellular space, or the neural dynamics, or something else.
  • Are purely descriptive studies okay or should we always search for mechanism
    • Who cares about things that you can see?!

Updates

  • Does dopamine have ‘a role’?
    • Should we try to claim some unified goal for dopamine, or is it just a molecule with many different downstream effects depending on the particular situation?
  • Do oscillations (‘alpha waves’, ‘gamma waves’, etc) do anything?
    • Are they just epiphenomenon that are correlated with stuff? Or do they actually have a causative role?
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